Research Engineer at the Evry/Paris Saclay University
Research Engineer at the Evry/Paris Saclay University, Gilles Lemaitre obtained his PhD in 2004 at the Department of Cell Biology and Functional Genomics of the CEA (French atomic energy agency). He identified markers of proliferation and differentiation of human epidermal keratinocytes using large-scale transcriptomic and proteomic analysis. By this way, he identified a new membrane marker of keratinocyte progenitors. Since his arrival at I-Stem (INSERM U861-Evry university), an institute dedicate to propose therapeutic approaches using human pluripotent stem cell (hPSC), he is responsible to participate in the development of a protocol for differentiation of human pluripotent stem cells into keratinocytes. Currently, he leads a translational project of "Tissue/cell therapy" by implementing a fully clinical grade protocol to obtain keratinocytes from hPSC and transfer the knowledge to an ATMP (Advanced therapy medicinal products) manufacturing facility. In parallel, he elaborates a catalogue of quality controls and has in charge of preclinical safety assays focus on animal experiments (teratoma - biodistribution and grafting). Based on his knowledge on epidermal biology, he paves the way to regenerative medicine of skin injuries using pluripotent stem cells.